Receptors and Effects on different organs.

Effects of both Sympathetic and Parasympathetic divisions on different organs.

Sympathetic receptors         α1, α2

                                                   β 1, β  2, β  3

parasympathetic  receptors     M1,M2,M3

1-      Cardio-vascular system

a-      Heart

Target site	Sympathetic	Parasympathetic
Cardiac output	(β1) increases	(M2) decreases
SA node: heart rate (Chronotropic )	(β1) increases	(M2) decreases
Contractility  (Inotropic)	(β1) increases	(M2) decreases
AV node	(β1) increases condution	(M2) decreases conduction

b-      Blood Vessels

Target site	Sympathetic	Parasympathetic
Skin,Brain,Kidney,Erectile tissue,salivary glands, Viscera	(α1)constriction	Erectile tissues and salivary glands only (M3) dilates
Hepatic , skeletal muscle, coronary arteries	(β2)dilates	______________

c-       Others :

Target site	Sympathetic	Parasympathetic
Platelets	(α2) aggregation	--------------
Mast cells (release of histamine)	(β2) inhibition	--------------

2-      Respiratory system :

Target site	Sympathetic	Parasympathetic
Smooth muscles of bronchioles	(β2) relaxation of muscles	(M2) contraction

3-      Eye

Target site	sympathetic	Parasympathetic
Iris radial muscle	(α1)pupil dilates( mydriasis )	------------
Iris sphincter muscle	--------------	(M3) pupil contracts (Miosis)
Ciliary muscle	(β2)relaxe                                              long range focus	(M3)contract                                    short range focus

4-      GIT

Target site	Sympathetic	Parasympathetic
GIT motility	decrease	M3, (M1) increases
GIT sphincters	(α1) contracts	M3 relaxation
GIT glands	---------------	(M3) increase secretions

5-      Urinary System

Target site	Sympathetic	Parasympathetic
Detrusor	(β2) relaxation	(M3) contraction
Urethral sphincter	(α1) contraction	(M3) Relaxation

 Sympathetic cause retention    while  parasympathetic cause evacuation

6-      Reproductive system

Target site	Sympathetic	Parasympathetic
Uterus  (female)	(β2) relaxation	-------------------
Genitalia (male)	(α1) ejaculation	(M3) Erection

7-      Metabolism

Target site	Sympathetic	Parasympathetic
Liver	(β2) glycogenolysis and gluconeogenesis	----------------
Kidney	(β1) increase rennin release	------------
Pancreas	(β2) increase insulin release(minor effect) (α2)decrease insulin release(major effect)

8-      Adipose tissue

(β1) cause lipolysis

9-      Skin: 

  α1 cause   stimulation of arrector pili